Inhibición de la ciclooxigenasa y de la síntesis de Prostaglandinas E2 por el Mangostán
Keigo Nakatania, Norimichi Nakahatab, Tsutomu Arakawac, Hideyuki Yasudac and
Yasushi Ohizumia Biochem Pharmacol. 2002 Jan 1; 63(1):73-9.
La cáscara del mangostán ha sido utilizada durante muchos años como una medicina para tratar infecciones de la piel,heridas y diarrea en el SE asiático. Han estudiado el efecto de Gamma mangosteen, una xantona, demostrando que inhibe la Cox2 y posee potente actividad inhibitoria de la liberación de prostaglandina E2(PGE2)
Inhibición de la liberación de Histamina y de la síntesis de prostaglandina E2 por el Mangostán, una planta medicinal de Tailandia
Nakatani K, Atsumi M, Arakawa T, Oosawa K, Shimura S, Nakahata N, Ohizumi Y. Biol Pharm Bull. 2002 Sep; 25(9):1137-41.
Los investigadores han descubierto que el extracto de la fruta del Mangostán inhibe fuertemente la liberación de histamina y la síntesis de prostaglandina E2. Esto tiene mucha importancia en prevención de alergias
Nuevas propiedades médicas del Mangostán: actividad analgésica de los ingredientes activos de la cáscara del Mangostán
New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana
L.Cui J, Hu W, Cai Z, Liu Y, Li S, Tao W, Xiang H. Department of Biological Science and Technology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong Province 510275, People's Republic of China.
The fruit hull of Garcinia mangostana L. contains oxygenated and prenylated phenol derivatives, such as xanthones or xanthen-9H-ones, and is used by people in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, suppuration, and chronic ulcer. We isolated the active ingredients from the crude ethanol extract of G.mangostana L. (CEM) and investigated their analgesic effects and underlying mechanisms. CEM at intragastric (i.g.) doses of 0.5, 1, and 3 g/kg clearly exhibited antinociceptive effects in the hot-plate and acetic acid-induced writhing tests in mice. Two isolated compounds, alpha-mangostin and gamma-mangostin, exhibited analgesic effects at doses of 25 and 50 mg/kg (i.g.) in the hot-plate and formalin tests, respectively. CEM at doses of 0.5, 1, and 3 g/kg significantly inhibited xylene-induced release of inflammatory mediators. CEM, alpha-mangostin, and gamma-mangostin each dose-dependently demonstrated the ability to scavenge reactive oxygen species. In conclusion, our results demonstrate that CEM and mangostins possess potent peripheral and central antinociceptive effects in mice and suggest that xanthones may be developed as novel analgesics and anti-inflammatory drugs.
PMID: 20064550 [PubMed - indexed for MEDLINE]
Las Xantonas pueden ser utilizadas para desarrollar nuevos medicamentos analgésicos y antiinflamatorios
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